1424348-25-3Relevant academic research and scientific papers
Design, synthesis, and antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton
Kuchkova, Kaleria,Aricu, Aculina,Secara, Elena,Barba, Alic,Vlad, Pavel,Ungur, Nicon,Tuchilus, Cristina,Shova, Sergiu,Zbancioc, Gheorghita,Mangalagiu, Ionel I.
, p. 1559 - 1568 (2014/03/21)
Herein we report a feasible study concerning the design, synthesis, and in vitro antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton. The reaction pathway is efficient and straight, involving the direct N-acylation of diazine with homodrimane sesquiterpenoids bearing acyl chlorides or organic acids functionality. A reliable explication and a feasible reaction mechanism for the obtained compounds are presented. The in vitro antimicrobial activity of the homodrimane sesquiterpenoids with and without diazine skeleton has been evaluated. All the tested compounds have an excellent antibacterial activity against Gram-positive strains S. aureus and B. cereus. SAR correlations concerning antimicrobial activity are reported. Graphical Abstract: The design, synthesis, and in vitro antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton are described. Antimicrobial tests prove that some homodrimane sesquiterpenoids have an excellent biological activity.[Figure not available: see fulltext.]
An efficient and straightforward method to new organic compounds: Homodrimane sesquiterpenoids with diazine units
Kuchkova, Kaleria,Aricu, Aculina,Barba, Alic,Vlad, Pavel,Shova, Sergiu,Secara, Elena,Ungur, Nicon,Zbancioc, Gheorghitǎ,Mangalagiu, Ionel I.
, p. 697 - 700 (2013/05/09)
A comprehensive study of the synthesis and structure of new homodrimane sesquiterpenoids with diazine skeleton is presented. This is the first synthesis of homodrimane sesquiterpenoids with diazine skeleton. In the same time, an efficient way for the one-
