*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate
• CAS No.: 101250-07-1
• Molecular Formula: C₂₁H₃₃N₃O₄
• Molecular Weight: 391.511

Synonyms:*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

Chemical Property of *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

There total 6 articles about *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(2-Methylpropyl)-aziridine (23852-57-5) → *,R*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate (101250-07-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 90.5 percent / Et₃N / diethyl ether / 1 h / 0 °C

2: 17.6 g / ethanol / 48 h / Heating

3: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

4: 2.) 5A molecular sieves, 2.) NaCNBH₃, bromcresol, HCl gas

5: trifluoroacetic acid (TFA)

With hydrogenchloride; 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate (101250-56-0) → *,R*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate (101250-07-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 2.) 5A molecular sieves, 2.) NaCNBH₃, bromcresol, HCl gas

4: trifluoroacetic acid (TFA)

With hydrogenchloride; 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester (101250-58-2) → *,R*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate (101250-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

2: 2.) 5A molecular sieves, 2.) NaCNBH₃, bromcresol, HCl gas

3: trifluoroacetic acid (TFA)

With hydrogenchloride; 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00156a012

upstream raw materials:

(S)-2-({(S)-1-[(tert-Butoxycarbonylmethyl-amino)-methyl]-3-methyl-butylamino}-methyl)-pyrrolidine-1-carboxylic acid benzyl ester

(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester

(S)-2-(2-Methylpropyl)-aziridine

((S)-2-Amino-4-methyl-pentylamino)-acetic acid tert-butyl ester

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