5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Base Information

Chemical Name:5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine
CAS No.:1589534-97-3
Molecular Formula:C₁₉H₂₂N₄O₃S₂
Molecular Weight:418.541
Hs Code.:

Synonyms:5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Chemical Property of 5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Technology Process of 5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

There total 15 articles about 5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1572928-14-3
tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1589534-97-3
5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm5000497

Reference yield:

: 1361224-49-8
benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-oxo-3-pentyn-1-yl)-carbamate

: 1589534-97-3
5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: trifluoroacetic acid / dichloromethane / -10 - 20 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 2.17 h / 20 °C

3.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C

4.1: Chiralpak^?ADH column / ethanol / Supercritical conditions; Resolution of racemate

5.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

6.1: DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 80 - 100 °C / Inert atmosphere

7.1: sulfuric acid / chloroform / 0 - 20 °C

8.1: triethylamine / dichloromethane / 0.08 h / 20 °C

8.2: 20 °C

9.1: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; In ethanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jm5000497

Reference yield:

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 1589534-97-3
5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C

2.1: Chiralpak^?ADH column / ethanol / Supercritical conditions; Resolution of racemate

3.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

4.1: DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 80 - 100 °C / Inert atmosphere

5.1: sulfuric acid / chloroform / 0 - 20 °C

6.1: triethylamine / dichloromethane / 0.08 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; In ethanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jm5000497