(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Base Information

Chemical Name:(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol
CAS No.:909913-44-6
Molecular Formula:C₂₄H₃₅NO₄Si
Molecular Weight:429.632
Hs Code.:

Synonyms:(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Suppliers and Price of (2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

There total 12 articles about (2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 909913-41-3
(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-2-methyl-3-propanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 909913-44-6
(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.tetasy.2006.06.010

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 909913-44-6
(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / NaH / dimethylformamide; various solvent(s) / 0 °C

2: m-chloroperbenzoic acid / CHCl₃ / 0 - 20 °C

3: 95 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

4: Zn / benzene / 1.5 h / Heating

5: 81 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

6: 87 percent / Pseudomonas sp. lipase / diisopropyl ether / 12 h / 33 °C

7: 93 percent / imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; Pseudomonas sp. lipase; sodium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; dichloromethane; chloroform; di-isopropyl ether; N,N-dimethyl-formamide; benzene; 3: Swern oxidation / 4: Reformatsky reaction;
DOI:10.1016/j.tetasy.2006.06.010

Reference yield:

: 63793-98-6
5-benzyloxy-2-methyl-pyridine

: 909913-44-6
(2S,3S)-1-acetoxy-3-[2-(5-benzyloxypyridyl)]-3-tert-butyldimethylsilyloxy-2-methyl-3-propanol

Guidance literature:: Multi-step reaction with 7 steps

1: m-chloroperbenzoic acid / CHCl₃ / 0 - 20 °C

2: 95 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

3: Zn / benzene / 1.5 h / Heating

4: 81 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

5: 87 percent / Pseudomonas sp. lipase / diisopropyl ether / 12 h / 33 °C

6: 93 percent / imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; Pseudomonas sp. lipase; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; dichloromethane; chloroform; di-isopropyl ether; N,N-dimethyl-formamide; benzene; 2: Swern oxidation / 3: Reformatsky reaction;
DOI:10.1016/j.tetasy.2006.06.010