(S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

Base Information

Chemical Name:(S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide
CAS No.:1395408-71-5
Molecular Formula:C₁₈H₂₃N₂PS
Molecular Weight:330.434
Hs Code.:

Synonyms:(S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

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Chemical Property of (S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

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Technology Process of (S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

There total 7 articles about (S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1157849-50-7,1157849-51-8
C₆H₁₄N₂*(x)ClH

: 1015-37-8
diphenylthiophosphinoyl chloride

: 1395408-71-5
(S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol302005f

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 1395408-71-5
(S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 16.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 10.25 h / 0 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate; calcium chloride / ethanol / 4 h / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / Inert atmosphere

5: 16 h / 20 °C / Inert atmosphere

6: methanol; hydrogenchloride / water / 16 h / 0 - 20 °C / Inert atmosphere

7: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; thionyl chloride; triethylamine; calcium chloride; In ethanol; dichloromethane; water;
DOI:10.1021/ol302005f

Reference yield:

: 162955-48-8,397246-12-7
[(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester

: 1395408-71-5
(S)-N-(1-methylpiperidine-3-yl)-P,P-diphenylphosphinthioic amide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / Inert atmosphere

2: 16 h / 20 °C / Inert atmosphere

3: methanol; hydrogenchloride / water / 16 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; triethylamine; In dichloromethane; water;
DOI:10.1021/ol302005f