35824-85-2

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-5-formyl-1,3-dimethyluracil is utilized as an active pharmaceutical ingredient for its antitumor properties, targeting the inhibition of thymidine phosphorylase to disrupt DNA synthesis in cancer cells. This action contributes to the suppression of tumor growth and the management of various cancer types.
Used in Antiviral Applications:
In the field of virology, 6-Chloro-5-formyl-1,3-dimethyluracil is employed as an antiviral agent, leveraging its ability to interfere with viral replication processes by inhibiting key enzymes, thereby limiting the spread of viral infections.
Used in Agrochemical Industry:
6-Chloro-5-formyl-1,3-dimethyluracil is used as a starting material in the synthesis of various agrochemicals, including pesticides and herbicides. Its role in these applications is to provide a foundation for the development of compounds that can effectively control pests and weeds in agricultural settings.
Used in Chemical Synthesis:
6-Chloro-5-formyl-1,3-dimethyluracil serves as a key intermediate in the synthesis of a range of pharmaceuticals and agrochemicals. Its unique structure allows for the creation of diverse derivatives with specific biological activities, enhancing the development of new therapeutic agents and agricultural products.

InChI:InChI=1/C7H7ClN2O3/c1-9-5(8)4(3-11)6(12)10(2)7(9)13/h3H,1-2H3

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 114142-97-1 6-(Furan-2-ylmethyl-p-tolyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 116360-58-8 6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 114142-96-0 6-[Furan-2-ylmethyl-(4-methoxy-phenyl)-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 116360-55-5 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 114142-95-9 6-[(4-Ethoxy-phenyl)-furan-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 89550-03-8 6-Chloro-1,3-dimethyl-5-(methyl-phenyl-hydrazonomethyl)-1H-pyrimidine-2,4-dione 
• 155185-72-1 6-Chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid phenylamide 
• 89550-02-7 6-Chloro-1,3-dimethyl-5-[(4-nitro-phenyl)-hydrazonomethyl]-1H-pyrimidine-2,4-dione 
• 114143-07-6 6-(Allyl-phenyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 109519-90-6 6-(N-propargyl)benzylaminopyrimidine-2,4(1H,3H)-dione-5-carbaldehyde 
• 147743-24-6 6-(N-allylbenzylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine 5-carboxaldehyde 
• 114143-08-7 6-[Allyl-(4-methoxy-phenyl)-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 114142-99-3 6-[(4-Chloro-phenyl)-furan-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 114142-98-2 6-[(4-Bromo-phenyl)-furan-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of some novel annulated pyrido[2,3-d] pyrimidines via stereoselective intramolecular hetero Diels-Alder reactions of 1-oxa-1,3-butadienes

Some novel annulated pyrido[2,3-d]pyrimidines 6 and 7 were synthesized stereoselectively by intramolecular hetero Diels-Alder reactions involving 1-oxa-1,3-butadienes.

PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS

The present invention is related to novel pyrimidinedione-fused heterocyclic compounds as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

The synthesis of pyrimidineisothiazolones. The effect of temperature on the addition of aryl amines to functionalized pyrimidines

A new synthesis for the hither-to-unknown pyrimidine isothiazolones 1 and 2 is detailed. The low temperature selectivity of amine nucleophiles on 6-chloropyrimidine-5-acylbromides (12) for the acylbromide over the ring chloride provides a new procedure fo

Studies on Pyrimidine-Annelated Heterocycles; 8. Intramolecular Cycloaddition of Thiophene and Nitrile Oxide or Nitrone Groups Bonded to 1,3-Dimethyluracils

1,3-Dimethyluracils having a nitrile oxide moiety or a nitronomethyl group at C-5 and an N-aryl-2-thienylmethylamino group at C-6 undergo an intramolecular cycloaddition reaction to give novel uracil-fused heterocycles.

Studies of Pyrimidine-2,4-diones: Synthesis of Novel Condensed Pyridopyrimidines via Intramolecular Cycloadditions

Suitably functionalised pyrimidine-2,4-diones (1) cyclised intramolecularly to yield the novel furoisoxazolopyridopyrimidines (5) and (9) in excellent yields.Remarkably, the pyrimidone nucleus was unaffected nor were there any side-reactions in this synthesis.