phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

Base Information

Chemical Name:phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate
CAS No.:1254367-63-9
Molecular Formula:C₂₅H₂₉N₃O₃
Molecular Weight:419.524
Hs Code.:

Synonyms:phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

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Chemical Property of phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

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Technology Process of phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

There total 11 articles about phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 107-10-8,42939-71-9
propylamine

: 1254367-60-6
phenyl 3-(benzyloxy)-2-bromo-6-(dimethylamino)-5-methylisonicotinate

: 1254367-63-9
phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

Guidance literature:: With potassium phosphate; copper(l) iodide; 2-acetylcyclohexanone; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

Reference yield:

: 1254367-44-6
C₂₀H₁₆BrNO₄

: 1254367-63-9
phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / toluene / 0.75 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; 1,4-dioxane / 4 h / 60 °C / Inert atmosphere

3: copper(l) iodide; anhydrous dipotassium phosphate; 2-acetylcyclohexanone / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; anhydrous dipotassium phosphate; 2-acetylcyclohexanone; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm1015389

Reference yield:

: 1254367-40-2
phenyl 3-(benzyloxy)-2,6-dibromo-5-methylisonicotinate

: 1254367-63-9
phenyl 5-benzyloxy-2-(dimethylamino)-3-methyl-6-(propylamino)isonicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; 1,4-dioxane / 4 h / 60 °C / Inert atmosphere

2: copper(l) iodide; anhydrous dipotassium phosphate; 2-acetylcyclohexanone / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; anhydrous dipotassium phosphate; 2-acetylcyclohexanone; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm1015389