4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

Base Information

Chemical Name:4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol
CAS No.:86064-57-5
Molecular Formula:C₂₄H₃₄N₂O₃
Molecular Weight:398.546
Hs Code.:

Synonyms:4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

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Chemical Property of 4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

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Technology Process of 4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

There total 12 articles about 4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 86045-71-8
6aα-ethyl-8aα-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-1,2,4,6a,7,8,8a,8bα-octahydro-1-oxacyclopentindolizin-2-one

: 86064-57-5
4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

Guidance literature:: With potassium hydroxide; In methanol; water; for 36h; Heating;
DOI:10.1021/jo00164a011

Reference yield:

: 59557-92-5
2-bromo-5-methoxyaniline

: 86064-57-5
4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

Guidance literature:: Multi-step reaction with 5 steps

2: 88 percent / KCN-18-crown-6-complex / CHCl₃ / 0.5 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C to room temp., 15 min, 2.) -78 deg C to room temp., 36 h

5: 50 percent / KOH / methanol; H₂O / 36 h / Heating

With potassium hydroxide; n-butyllithium; (K-18-crown-6 ether) cyanide; In methanol; chloroform; water;
DOI:10.1021/jo00164a011

Reference yield:

: 3282-30-2
pivaloyl chloride

: 86064-57-5
4aα-ethyl-7α-<1-<4-methoxy-2-(trimethylacetamido)-phenyl>ethenyl>-2,4a,5,6,7,7aα-hexahydro-1H-1-pyrindin-7-ol

Guidance literature:: Multi-step reaction with 5 steps

2: 88 percent / KCN-18-crown-6-complex / CHCl₃ / 0.5 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C to room temp., 15 min, 2.) -78 deg C to room temp., 36 h

5: 50 percent / KOH / methanol; H₂O / 36 h / Heating

With potassium hydroxide; n-butyllithium; (K-18-crown-6 ether) cyanide; In methanol; chloroform; water;
DOI:10.1021/jo00164a011