1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene

Base Information

• Chemical Name: 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene
• CAS No.: 1401715-73-8
• Molecular Formula: C₁₀H₉F₃OS
• Molecular Weight: 234.242
• Mol file: 1401715-73-8.mol

Synonyms:1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene

Chemical Property of 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene

Chemical Property:

Purity/Quality:

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Technology Process of 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene

There total 17 articles about 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(E)-4-(2-bromo-vinyl)-anisole (6303-59-9,60592-52-1,27570-08-7) + (2,2'-bipyride-kN1,kN1')(1,1,1-trifluoromethanethiolato-kS)-copper (1413732-47-4) → 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene (1401715-73-8)

Guidance literature:

With potassium fluoride; In diethylene glycol dimethyl ether; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00144

Reference yield: 86.0%

4-Methoxystyrene (637-69-4,24936-44-5) + N-(benzenesulfonyl)-N-[(trifluoromethyl)sulfanyl]benzenesulfonamide → 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene (1401715-73-8)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 1h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.6b01178

Reference yield: 85.0%

1-methoxy-4-(2-nitro-vinyl)-benzene (3179-10-0) + silver(I) trifluoromethanethiolate (811-68-7) → 1-methoxy-4-[(E)-2-[(trifluoromethyl)sulfanyl]ethenyl]benzene (1401715-73-8)

Guidance literature:

With ammonium peroxydisulfate; dipotassium hydrogenphosphate; copper(II) trifluoroacetate; In dimethyl sulfoxide; at 60 ℃; for 6h; stereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01714

upstream raw materials:

(E)-2-(4-methoxyphenyl)vinylboronic acid

Copper(I) trifluoromethanethiolate

2-iodo-1-(4-methoxyphenyl)ethylene

(E)-4-(2-bromo-vinyl)-anisole