7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

• Chemical Name: 7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS No.: 1407510-82-0
• Molecular Formula: C₂₈H₃₇FN₄O₆
• Molecular Weight: 544.623
• Mol file: 1407510-82-0.mol

Synonyms:7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property of 7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 2 articles about 7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) + ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) → 7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1407510-82-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2015.07.010

Reference yield: 45.0%

chloro-trimethyl-silane (75-77-4) + 6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) + ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) → 7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1407510-82-0)

Guidance literature:

chloro-trimethyl-silane; ciprofloxacin; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

6-(tert-butoxycarbonylamino)hexanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ja3077268

upstream raw materials:

chloro-trimethyl-silane

6-(tert-butoxycarbonylamino)hexanoic acid

ciprofloxacin