C₂₂H₂₀N₂O₄

Base Information

• Chemical Name: C₂₂H₂₀N₂O₄
• CAS No.: 1381986-12-4
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.412
• Mol file: 1381986-12-4.mol

Synonyms:C₂₂H₂₀N₂O₄

Chemical Property of C₂₂H₂₀N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀N₂O₄

There total 1 articles about C₂₂H₂₀N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-carbomethoxyaniline (134-20-3) + 2,3-dibromobenzene (583-53-9) → C22H20N2O4 (1381986-12-4)

Guidance literature:

With tri-tert-butyl phosphine; palladium diacetate; caesium carbonate; In toluene; Inert atmosphere; Reflux;

DOI:10.1021/ol401812h

Reference yield: 96.9%

C22H20N2O4 (1381986-12-4) → o-phenylenedianthranilic acid (28394-82-3)

Guidance literature:

With potassium hydroxide; In methanol; water; for 10h; Inert atmosphere; Reflux;

DOI:10.1021/ol401812h

Reference yield:

C22H20N2O4 (1381986-12-4) → C36H30N4O2 (1448522-45-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol; water / 10 h / Inert atmosphere; Reflux

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 5 - 20 °C / Inert atmosphere

3: triphenylphosphine; triethylamine; tetrachloromethane / acetonitrile / 20 °C / Inert atmosphere

With tetrachloromethane; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;

DOI:10.1021/ol401812h

upstream raw materials:

2-carbomethoxyaniline

2,3-dibromobenzene

Downstream raw materials:

C₃₆H₃₀N₄O₂

C₃₀H₃₄N₄O₂

C₃₈H₃₄N₄O₂

C₃₂H₃₈N₄O₂