28394-82-3

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 118-91-2 ortho-chlorobenzoic acid 
• 7732-18-5 water 
• 1381986-12-4 C₂₂H₂₀N₂O₄ 
• 134-20-3 2-carbomethoxyaniline 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 28394-83-4 N,N'-diphenyl-o-phenylenediamine 
• 1448522-45-9 C₃₆H₃₀N₄O₂ 
• 1448522-46-0 C₃₀H₃₄N₄O₂ 
• 1448522-48-2 C₃₈H₃₄N₄O₂ 
• 1448522-49-3 C₃₂H₃₈N₄O₂ 
• 1448522-54-0 C₃₆H₃₄N₄O₄ 
• 1448522-55-1 C₃₀H₃₈N₄O₄ 
• 1448522-56-2 C₃₈H₃₈N₄O₄ 
• 1448522-57-3 C₃₂H₄₂N₄O₄ 
• 1448522-58-4 C₃₂H₄₂N₄O₄ 

Relevant academic research and scientific papers

Method for preparing aldehydes or ketones through olefin oxidation

The invention relates to a method for preparing aldehydes or ketones through catalytic oxidation of olefins by taking chiral tetradentate nitrogen organic compounds as ligands and taking metallic compounds as catalysts. According to the technical scheme, the method comprises the following steps: by taking four-tooth nitrogen organic compounds and metallic compounds as a catalytic system, and taking olefins as a substrate, reacting in the presence of an oxidizing agent, thereby obtaining the product aldehydes or ketones. The reaction temperature is 25-120 DEG C, the reaction time is 1-12 hours,the molar ratio of the chiral four-tooth nitrogen organic ligands to metal elements is 1:10 to 10:1, the molar ratio of the chiral four-tooth nitrogen organic ligands to the substrate olefins is 1:3000 to 1:100, and the molar ratio of the olefins to the oxidizing agent is 1:10 to 1:1. The method for preparing aldehydes or ketones through olefin oxidation provided by the invention is simple to operate, has high catalytic activity and selectivity and also has great industrialized application prospects.

A catalytic asymmetric oxidizing thioether preparation of chiral pharmaceutical method

The invention provides a preparation method of a chiral sulfoxide medicament though catalysis of asymmetric oxidation of sulfides compounds. A chiral complex formed by quadridentate nitrogen organic ligand and metal manganese compound as a catalyst and hydrogen peroxide as an oxidant are used for asymmetric catalytic oxidation of prochiral thioether compound, so as to obtain the corresponding chiral sulfoxide medicament compounds including S-omeprazole, S-lansoprazole, S-pantoprazole, S-rabeprazole, R-Modafinil and R-sulindac. The reaction has the advantages of cleaness, mild reaction conditions, high conversion rate and antipodal selectivity, and shows industrial prospects.

Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide

We have successfully reported here the low loading porphyrin-inspired high-valent manganese (IV)-oxo complex was applied in oxidative kinetic resolution (OKR) of racemic heterocyclic sulfoxides using the environmentally benign hydrogen peroxide for the first time. This approach allows for rapid OKR (0.5 h) of a variety of racemic sulfoxides (including pyridine, pyrimidine, pyrazine, thiazole, benzothiazole, thiophene) in excellent enantioselectivity (up to > 99% ee), simultaneously generating the corresponding sulfones in high yield (up to 80%). The catalytic system also showed an unexceptionable chemoselectivity for the sulfoxide substrates with hydroxyl groups in which only the sulfoxide group was oxidized. The practical utility of the method has been demonstrated in the OKR of gram-scale sulfoxides.

A catalytic asymmetric oxidation of sulfide method

The invention provides a method for asymmetric catalytic oxidation of thioether. A chiral complex formed by a quadridentate nitrogen organic ligand and a metal manganese compound is adopted as the catalyst, hydrogen peroxide is employed as the oxidizing agent to carry out asymmetric catalytic oxidation reaction on thioether so as to obtain a corresponding chiral sulfoxide compound, and the yield and enantioselectivity are both greater than 95%. The reaction has the advantages of cleanliness, mild reaction conditions, high conversion rate and enantioselectivity, and has industrial prospect.

A nitrogen-containing four the tooth is organic biligand synthetic method

A synthetic method for preparing a ligand with a chemical formula shown in the specification is provided. In the chemical formula, R1, R2 and R3 are hydrogen, alkyl, aryl, arylalkyl or alkoxyl, and are same or different, and X is O, S or N. The invention also discloses application of the ligand to combine with a transition metal for catalyzing asymmetric alkene epoxidation reaction.

A process for the asymmetric epoxidation of olefins

The invention provides an method for asymmetrically catalytically epoxidizing non-functionalized alkenes. A chiral complex formed by a tetra-dentate nitrogen organic ligand and a metal manganese manganese compound formation is employed as a catalyst, and

Asymmetric epoxidation of alkenes catalyzed by a porphyrin-inspired manganese complex

A novel strategy for catalytic asymmetric epoxidation of a wide variety of olefins by a porphyrin-inspired chiral manganese complex using H 2O2 as a terminal oxidant in excellent yield with up to greater than 99% ee has been successfully developed.