(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate
CAS No.:1466528-32-4
Molecular Formula:C₂₄H₂₉N₃O₂
Molecular Weight:391.513
Hs Code.:

Synonyms:(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

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Chemical Property of (R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

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Technology Process of (R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

There total 6 articles about (R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

: 761446-45-1
1-(phenylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1466528-35-7
tert-butyl (R)-(1-(3-bromo-2-methylphenyl)ethyl)carbamate

: 1466528-32-4
(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

Guidance literature:: With sodium carbonate; In 1,4-dioxane; at 95 ℃; for 7h; Inert atmosphere;

Reference yield:

: 52780-15-1
3'-bromo-2'-methylbenzonitrile

: 1466528-32-4
(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 - 50 °C / Inert atmosphere

1.2: 2 h / 0 - 50 °C / Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 75 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 1.5 h / -50 - 0 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 20 h / 20 °C

6.1: sodium carbonate / 1,4-dioxane / 7 h / 95 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane;

Reference yield:

: 52779-76-7
1-(3-bromo-2-methylphenyl)ethan-1-one

: 1466528-32-4
(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 75 °C

2: sodium tetrahydroborate / tetrahydrofuran / 1.5 h / -50 - 0 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

4: triethylamine / dichloromethane / 20 h / 20 °C

5: sodium carbonate / 1,4-dioxane / 7 h / 95 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;