3'-broMo-2'-Methylacetophenone

Base Information

• Chemical Name: 3'-broMo-2'-Methylacetophenone
• CAS No.: 52779-76-7
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.074
• Hs Code.: 2914700090
• Mol file: 52779-76-7.mol

Synonyms:

Chemical Property of 3'-broMo-2'-Methylacetophenone

Chemical Property:

• Boiling Point: 272.7±28.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.388±0.06 g/cm3(Predicted)
• LogP: 2.96010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(3-bromo-2-methylphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-broMo-2'-Methylacetophenone

There total 5 articles about 3'-broMo-2'-Methylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

3-bromo-N-methoxy-2, N-dimethylbenzamide (631909-08-5) + methylmagnesium bromide (75-16-1) → 1-(3-bromo-2-methylphenyl)ethan-1-one (52779-76-7)

Guidance literature:

In tetrahydrofuran; at 0 - 40 ℃; for 3h;

Reference yield: 68.2%

3'-bromo-2'-methylbenzonitrile (52780-15-1) + methylmagnesium bromide (75-16-1) → 1-(3-bromo-2-methylphenyl)ethan-1-one (52779-76-7)

Guidance literature:

3'-bromo-2'-methylbenzonitrile; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 50 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 0 - 50 ℃; for 2h; Inert atmosphere;

Reference yield:

3'-bromo-2'-methylbenzonitrile (52780-15-1) + methyl iodide (74-88-4) → 1-(3-bromo-2-methylphenyl)ethan-1-one (52779-76-7)

Guidance literature:

With magnesium; In hydrogenchloride; ice-water;

upstream raw materials:

3'-bromo-2'-methylbenzonitrile

methyl iodide

methylmagnesium bromide

3-bromo-2-methylbenzoic acid

Downstream raw materials:

(R)-N-(1-(3-bromo-2-methylphenyl)ethyl)-2-methylpropane-2-sulfonamide

(R)-1-(3-bromo-2-methylphenyl)ethanamine

tert-butyl (R)-(1-(3-bromo-2-methylphenyl)ethyl)carbamate

(R)-tert-butyl 1-(3-(1-benzyl-1H-pyrazol-4-yl)-2-methylphenyl)ethylcarbamate

Refernces

• 1、 -. "Aromatic ring-containing compound and application thereof". . . Retrieved 2019/10/01.
• 2、 -. "PYRIMIDINONE CARBOXAMIDES AS INHIBITORS OF ENDOTHELIAL LIPASE". Paragraph 00193. . Retrieved 2013/10/22.