52780-15-1

Basic information

• Product Name: 3-BROMO-2-METHYLBENZONITRILE
• Synonyms: 3-Bromo-2-methylbenzonitrile98%;3-BROMO-2-METHYLBENZONITRILE
• CAS NO: 52780-15-1
• Molecular Formula: C₈H₆BrN
• Molecular Weight: 196.04394
• Mol File: 52780-15-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 44-45 °C
• Boiling Point: 247.546 °C at 760 mmHg
• Flash Point: 103.512 °C
• Appearance: /
• Density: 1.51 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BROMO-2-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-METHYLBENZONITRILE(52780-15-1)
• EPA Substance Registry System: 3-BROMO-2-METHYLBENZONITRILE(52780-15-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: 2811
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 52780-15-1(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-methylbenzonitrile is a chemical compound with the molecular formula C8H6BrN. It is a white to off-white crystalline powder with a molecular weight of 186.04 g/mol. This chemical is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of dyes, pigments, and other organic compounds. 3-Bromo-2-methylbenzonitrile is a highly reactive compound and should be handled with care, as it may cause skin and eye irritation upon contact. Additionally, it should be stored away from light, air, and moisture to prevent degradation.

Upstream product

• 55289-36-6 3-bromo-2-methylaniline 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 919363-09-0 3-bromo-2-methylbenzamide 
• 407-25-0 trifluoroacetic anhydride 
• 69321-60-4 2,6-dibromotoluene 
• 76006-33-2 3-bromo-2-methylbenzoic acid 

Downstream Products

• 1233479-42-9 1-bromo-2-(bromomethyl)-3-cyanobenzene 
• 35256-74-7 2-methyl-3-cyano-benzoyl chloride 
• 2239273-34-6 3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile 
• 3843-99-0 2-methyl-3-cyano-benzoic acid 
• 52779-94-9 2-[3-(2-thenoyl)-o-tolyl] acetic acid 
• 52779-93-8 2-methyl-3-(2-thenoyl)hydratropic acid 
• 52780-19-5 2-methyl-3-(2-thenoyl)hydratroponitrile 
• 52779-78-9 2'-methyl-3'-(2-thenoyl)acetophenone 
• 64382-46-3 3-(1-chloroethyl)-o-tolyl thien-2-yl ketone 
• 52779-79-0 3-(1-hydroxyethyl)-o-tolyl thien-2-yl ketone 
• 52779-77-8 2-(3-bromo-2-methylphenyl)-2-methyl-1,3-dioxolane 
• 109179-31-9 2-bromo-3-methyl-benzaldehyde 

Relevant articles and documents

PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS

Provided herein are improved processes for preparing aminopyrimidine compounds of Formula (I). The disclosed processes advantageously proceed through a β-diketoester intermediate of Formula (A) and avoid the direct linking of a pyrimidine and phenyl moiet

DIFLUOROMETHYLENE COMPOUND

The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA

Disclosed are novel compounds of formula (I) wherein R1, R2, R3 , R4 and A are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders