benzyl 3-amino-6-(4-methoxyphenyl)pyrazine-2-carboxylate 4-oxide

Base Information

• Chemical Name: benzyl 3-amino-6-(4-methoxyphenyl)pyrazine-2-carboxylate 4-oxide
• CAS No.: 113120-66-4
• Molecular Formula: C₁₉H₁₇N₃O₄
• Molecular Weight: 351.362
• Mol file: 113120-66-4.mol

Synonyms:2-amino-3-benzyloxycarbonyl-5-(p-methoxyphenyl)pyrazine 1-oxide

Chemical Property of benzyl 3-amino-6-(4-methoxyphenyl)pyrazine-2-carboxylate 4-oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzyl 3-amino-6-(4-methoxyphenyl)pyrazine-2-carboxylate 4-oxide

There total 4 articles about benzyl 3-amino-6-(4-methoxyphenyl)pyrazine-2-carboxylate 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

p-methoxy-isonitrosoacetophenone (1823-76-3) + benzyl alpha-aminocyanoacetate methanesulfonic acid salt (59319-89-0) → 2-amino-3-benzyloxycarbonyl-5-(p-methoxyphenyl)pyrazine 1-oxide (113120-66-4)

Guidance literature:

In methanol; for 120h;

Reference yield:

p-methoxyphenylglyoxal (1076-95-5) → 2-amino-3-benzyloxycarbonyl-5-(p-methoxyphenyl)pyrazine 1-oxide (113120-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / acetonoxime, 2 N HCl / H₂O; methanol / 2 h / 50 °C / pH 4

2: 76 percent / methanol / 120 h

With hydrogenchloride; acetone oxime; In methanol; water;

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 2-amino-3-benzyloxycarbonyl-5-(p-methoxyphenyl)pyrazine 1-oxide (113120-66-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / SeO₂ / H₂O; dioxane / 16 h / Heating

2: 86 percent / acetonoxime, 2 N HCl / H₂O; methanol / 2 h / 50 °C / pH 4

3: 76 percent / methanol / 120 h

With hydrogenchloride; selenium(IV) oxide; acetone oxime; In 1,4-dioxane; methanol; water;

upstream raw materials:

p-methoxy-isonitrosoacetophenone

benzyl alpha-aminocyanoacetate methanesulfonic acid salt

2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one

p-methoxyphenylglyoxal

Downstream raw materials:

2-amino-3-carbamoyl-5-(p-methoxyphenyl)pyrazine 1-oxide

6-p-tolyl-1H-pteridine-2,4-dione

6-(4-methoxy-phenyl)-1H-pteridine-2,4-dione

6-(p-methylphenyl)-4(3H)-pteridinone