Chemical Property of 2-(4-Methoxyphenyl)-2-oxoacetaldehyde
Chemical Property:
- Vapor Pressure:0.00921mmHg at 25°C
- Boiling Point:265.3°Cat760mmHg
- Flash Point:114.1°C
- Density:1.153g/cm3
- XLogP3:1.8
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:164.047344113
- Heavy Atom Count:12
- Complexity:169
- Purity/Quality:
-
97% *data from raw suppliers
2-(4-Methoxyphenyl)-2-oxoacetaldehyde *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=CC=C(C=C1)C(=O)C=O
-
General Description
**2-(4-Methoxyphenyl)-2-oxoacetaldehyde (also known as (p-methoxyphenyl)glyoxal or 4-methoxyphenylglyoxal)** is a reactive α-dicarbonyl compound featuring a methoxy-substituted phenyl ring attached to a glyoxal moiety. It serves as a key synthetic intermediate, notably in the preparation of bioactive alkaloids like eudistidine A, where it participates in condensation/cyclization cascades to form polycyclic scaffolds. Its electrophilic carbonyl groups enable diverse reactions, such as gold-catalyzed oxidations or multicomponent couplings, yielding heterocyclic derivatives with potential biological activities (e.g., antimalarial or enzyme inhibition). 2-(4-methoxyphenyl)-2-oxoacetaldehyde’s utility in constructing complex molecular architectures underscores its importance in medicinal and synthetic chemistry.
