Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester
CAS No.:212619-56-2
Molecular Formula:C₁₇H₁₄F₄O₄S
Molecular Weight:390.355
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

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Chemical Property of Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

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Technology Process of Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

There total 3 articles about Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 100-52-7
benzaldehyde

: 212619-47-1
(Z)-2-fluoro-2-trifluoromethylethenyl tosylate

: 212619-56-2
Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 deg C, 10 min, 2.) -78 deg C, 30 min;

Reference yield:

: 565-42-4
2,2,3,3,3-pentafluoro-1-propyl 4-toluenesulfonate

: 212619-56-2
Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / n-BuLi, 1,3-dimethylperhydropyrimidin-2-one / tetrahydrofuran; hexane / 0.17 h / -78 °C

2: 63 percent / n-BuLi, 1,3-dimethylperhydropyrimidin-2-one / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C, 30 min

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 212619-56-2
Toluene-4-sulfonic acid (Z)-2,3,3,3-tetrafluoro-1-(hydroxy-phenyl-methyl)-propenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 3 h / Ambient temperature

2: 67 percent / n-BuLi, 1,3-dimethylperhydropyrimidin-2-one / tetrahydrofuran; hexane / 0.17 h / -78 °C

3: 63 percent / n-BuLi, 1,3-dimethylperhydropyrimidin-2-one / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C, 30 min

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;