((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

Base Information

Chemical Name:((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone
CAS No.:952709-02-3
Molecular Formula:C₃₃H₅₄N₂O₇
Molecular Weight:590.801
Hs Code.:

((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

Synonyms:((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

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Chemical Property of ((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

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Technology Process of ((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

There total 9 articles about ((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884512-27-0
(S)-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)-1-((R)-piperidin-3-yl)pentan-1-ol hydrochloride

: 952708-31-5
(1S,3R,4S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-hydroxycyclopentanecarboxylic acid

: 952709-02-3
((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 634590-61-7
(4-methoxybutyl)magnesium chloride

: 952709-02-3
((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 2 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 130 °C / Microwave irradiation

4: hydrogenchloride; water / acetonitrile / 20 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; water; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2-((S)-1-hydroxy-5-methoxy-1-((R)-N-Boc-piperidin-3-yl)pentyl)phenol

: 952709-02-3
((1S,3R,4S)-3-(tert-butoxycarbonylamino)-4-hydroxycyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(2,2-(dimethyl)propoxy)phenyl)pentyl)piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 130 °C / Microwave irradiation

2: hydrogenchloride; water / acetonitrile / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; water; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;