(2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Base Information

Chemical Name:(2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol
CAS No.:191673-45-7
Molecular Formula:C₁₇H₂₇Cl₂N₃O₂Si
Molecular Weight:404.412
Hs Code.:

Synonyms:(2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Chemical Property:

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Technology Process of (2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

There total 8 articles about (2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 191673-44-6
(2R)-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)pentane-1,2-diol

: 191673-45-7
(2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Guidance literature:

Reference yield:

: methanesulfonic acid 5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-2-hydroxy-pentyl ester

: 191673-45-7
(2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 120 ℃;
DOI:10.1016/S0960-894X(99)00093-1

Reference yield:

: 50597-19-8
3-(3,4-dichlorobenzoyl)-propionic acid

: 191673-45-7
(2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Guidance literature:: Multi-step reaction with 7 steps

1: conc. H₂SO₄

2: 50 percent / t-BuOK / benzene

3: LiAlH₄ / tetrahydrofuran

4: Et₃N / CH₂Cl₂

5: AD-mix-β / 2-methyl-propan-2-ol; H2O

6: DMAP, pyridine

7: NaN₃ / dimethylformamide / 120 °C

With pyridine; dmap; lithium aluminium tetrahydride; sodium azide; AD-mix-β; sulfuric acid; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1016/S0960-894X(99)00093-1