N-alpha-t-Butyloxycarbonyl-L-isoleucinyl-diazomethane, (3S,4S)-3-Boc-amino-1-diazo-4-methyl-2-hexanone

Base Information

Chemical Name:N-alpha-t-Butyloxycarbonyl-L-isoleucinyl-diazomethane, (3S,4S)-3-Boc-amino-1-diazo-4-methyl-2-hexanone
CAS No.:114645-19-1
Molecular Formula:C₁₂H₂₁N₃O₃
Molecular Weight:255.317
Hs Code.:
Mol file:114645-19-1.mol

Synonyms:Carbamicacid, [(1S,2S)-1-(diazoacetyl)-2-methylbutyl]-, 1,1-dimethylethyl ester (9CI);Carbamic acid, [1-(diazoacetyl)-2-methylbutyl]-, 1,1-dimethylethyl ester,[S-(R*,R*)]-

Suppliers and Price of N-alpha-t-Butyloxycarbonyl-L-isoleucinyl-diazomethane, (3S,4S)-3-Boc-amino-1-diazo-4-methyl-2-hexanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-alpha-t-Butyloxycarbonyl-L-isoleucinyl-diazomethane, (3S,4S)-3-Boc-amino-1-diazo-4-methyl-2-hexanone

Chemical Property:

PSA：92.79000
LogP:2.26746

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-alpha-t-Butyloxycarbonyl-L-isoleucinyl-diazomethane, (3S,4S)-3-Boc-amino-1-diazo-4-methyl-2-hexanone

There total 6 articles about N-alpha-t-Butyloxycarbonyl-L-isoleucinyl-diazomethane, (3S,4S)-3-Boc-amino-1-diazo-4-methyl-2-hexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 114645-19-1,497106-85-1
[(3S,4S)-N-tert-Butoxycarbonyl-L-isoleucyl]diazomethane

Guidance literature:: N-(tert-butyloxycarbonyl)-L-isoleucine; With pyridine; dmap; di-tert-butyl dicarbonate; In tetrahydrofuran; at 0 ℃;

diazomethane; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1039/b204652k

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 114645-19-1,497106-85-1
[(3S,4S)-N-tert-Butoxycarbonyl-L-isoleucyl]diazomethane

Guidance literature:: Multi-step reaction with 2 steps

1: NMM / tetrahydrofuran / 1 h / -25 °C

2: diethyl ether / 2 h / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(98)00675-3

Reference yield:

: 73-32-5,959215-79-3,18875-42-8
L-isoleucine

: 114645-19-1,497106-85-1
[(3S,4S)-N-tert-Butoxycarbonyl-L-isoleucyl]diazomethane

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / NaOH / 2-methyl-propan-2-ol; H₂O / 16 h / Ambient temperature; pH=8-9

2: 1) ClCO₂CH₂CH(CH₃)2, N(Et)3 / 1) THF, ether, -20 deg C, 0.5 h, 2) ether, -10 deg C to r. t., 3 h

With sodium hydroxide; triethylamine; isobutyl chloroformate; In water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)80473-7