3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid

Base Information

• Chemical Name: 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid
• CAS No.: 1207315-07-8
• Molecular Formula: C₂₇H₁₅Br₂F₈N₃O₄
• Molecular Weight: 757.229
• Mol file: 1207315-07-8.mol

Synonyms:3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid

Chemical Property of 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid

There total 2 articles about 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid (1207315-06-7) + 4-cyanobenzoyl chlorIde (6068-72-0) → 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid (1207315-07-8)

Guidance literature:

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid; 4-cyanobenzoyl chlorIde; With sodium hydroxide; In water; at 20 ℃; for 24h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

N-(2,6-dibromo-4-heptafluoroisopropylphenyl)-3-amino-2-fluorobenzamide (1207314-94-0) → 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid (1207315-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 h / 60 - 80 °C

2: sodium hydroxide / water / 24 h / 20 °C

With sodium hydroxide; In water;

Reference yield: 35.0%

3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid (1207315-07-8) + glycinamide hydrochloride (1668-10-6) → 3-(N-(3-(2-amino-2-oxoethylamino)-3-oxopropyl)-4-cyanobenzamide)-N-(2,6-dibromo-4-(perfluoropropan-2-yl)phenyl)-2-fluorobenzamide (1207315-05-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

upstream raw materials:

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid

4-cyanobenzoyl chlorIde

N-(2,6-dibromo-4-heptafluoroisopropylphenyl)-3-amino-2-fluorobenzamide

Downstream raw materials:

3-(N-(3-(2-amino-2-oxoethylamino)-3-oxopropyl)-4-cyanobenzamide)-N-(2,6-dibromo-4-(perfluoropropan-2-yl)phenyl)-2-fluorobenzamide