3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid

Base Information

• Chemical Name: 3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid
• CAS No.: 1207315-06-7
• Molecular Formula: C₁₉H₁₂Br₂F₈N₂O₃
• Molecular Weight: 628.111
• Mol file: 1207315-06-7.mol

Synonyms:3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid

Chemical Property of 3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid

There total 1 articles about 3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2,6-dibromo-4-heptafluoroisopropylphenyl)-3-amino-2-fluorobenzamide (1207314-94-0) + acrylic acid (79-10-7) → 3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid (1207315-06-7)

Guidance literature:

at 60 - 80 ℃; for 3h;

Reference yield: 60.0%

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid (1207315-06-7) + O-(tert-butyl)hydroxylamine hydrochloride (39684-28-1) → 3-(3-(tert-butoxyamino)-3-oxopropylamino)-N-(2,6-dibromo-4-(perfluoropropan-2-yl)phenyl)-2-fluorobenzamide (1207315-09-0)

Guidance literature:

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 1h;

O-(tert-butyl)hydroxylamine hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 36.0%

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid (1207315-06-7) + 4-cyanobenzoyl chlorIde (6068-72-0) → 3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid (1207315-07-8)

Guidance literature:

3-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenylamino)propanoic acid; 4-cyanobenzoyl chlorIde; With sodium hydroxide; In water; at 20 ℃; for 24h;

With hydrogenchloride; In water; ethyl acetate;

upstream raw materials:

N-(2,6-dibromo-4-heptafluoroisopropylphenyl)-3-amino-2-fluorobenzamide

acrylic acid

Downstream raw materials:

3-(4-cyano-N-(3-(2,6-dibromo-4-(perfluoropropan-2-yl)phenylcarbamoyl)-2-fluorophenyl)benzamide)propanoic acid

3-(3-(tert-butoxyamino)-3-oxopropylamino)-N-(2,6-dibromo-4-(perfluoropropan-2-yl)phenyl)-2-fluorobenzamide

3-(N-(3-(2-amino-2-oxoethylamino)-3-oxopropyl)-4-cyanobenzamide)-N-(2,6-dibromo-4-(perfluoropropan-2-yl)phenyl)-2-fluorobenzamide