(4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

Base Information

Chemical Name:(4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate
CAS No.:443119-45-7
Molecular Formula:C₁₉H₃₄O₄SSi
Molecular Weight:386.628
Hs Code.:

Synonyms:(4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

Suppliers and Price of (4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

Chemical Property:

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Technology Process of (4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

There total 7 articles about (4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 105859-48-1
(4S)-5-{[(tert-butyl)dimethylsilyl]oxy}-4-methylpentan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 443119-45-7
(4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/S0957-4166(02)00095-2

Reference yield:

: 97826-89-6
(2R)-3-(tert-butyldimethylsilyloxy)-2-methylpropanal

: 443119-45-7
(4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / benzene / 12 h / 20 °C

2: 82 percent / Mg / methanol / 4 h / 20 °C

3: 92 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 12 h / 20 °C

4: 85 percent / Et₃N / CH₂Cl₂ / 10 h / 20 °C

With sodium tetrahydroborate; magnesium; triethylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1016/S0957-4166(02)00095-2

Reference yield:

: 105859-44-7
methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate

: 443119-45-7
(4S)-5-tert-butyldimethylsilyloxy-4-methylpentyl 4-methyl-1-benzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / DIBAL-H / CH₂Cl₂ / 0 - 20 °C

2: 97 percent / chromium trioxide; pyridine / CH₂Cl₂ / 0.25 h / 20 °C

3: 82 percent / benzene / 12 h / 20 °C

4: 82 percent / Mg / methanol / 4 h / 20 °C

5: 92 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 12 h / 20 °C

6: 85 percent / Et₃N / CH₂Cl₂ / 10 h / 20 °C

With pyridine; chromium(VI) oxide; sodium tetrahydroborate; diisobutylaluminium hydride; magnesium; triethylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1016/S0957-4166(02)00095-2