toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

Base Information

Chemical Name:toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester
CAS No.:863888-32-8
Molecular Formula:C₂₅H₂₉ClN₂O₆S
Molecular Weight:521.034
Hs Code.:

Synonyms:toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

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Chemical Property of toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

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Purity/Quality:: 98%+ ^*data from raw suppliers

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Technology Process of toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

There total 15 articles about toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 863888-31-7
2-(tert-butyl)-4-chloro-5-((4-((2-hydroxyethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

: 98-59-9
p-toluenesulfonyl chloride

: 863888-32-8
toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 22h;
DOI:10.1021/jm701443n

Reference yield:

: 84956-71-8
2-tert-butyl-4,5-dichloro-2H-pyridazin-3-one

: 863888-32-8
toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

2.1: phosphorus tribromide / dichloromethane / 1 h / 25 °C

3.1: potassium tert-butylate / 60 °C

3.2: 16.5 h / 60 °C

4.1: dmap; triethylamine / dichloromethane / 22 h / 20 °C

With dmap; potassium tert-butylate; phosphorus tribromide; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 863888-28-2
4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

: 863888-32-8
toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: dmap; triethylamine / dichloromethane / 22 h / 20 °C

With dmap; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;