2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

Base Information

• Chemical Name: 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one
• CAS No.: 863888-33-9
• Molecular Formula: C₁₈H₂₂ClFN₂O₃
• Molecular Weight: 368.836
• Mol file: 863888-33-9.mol

Synonyms:2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

Chemical Property of 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

There total 8 articles about 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester (863888-32-8) → 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one (863888-33-9)

Guidance literature:

With potassium fluoride; [2.2.2]cryptande; In acetonitrile; at 90 ℃; for 0.166667h;

DOI:10.1021/jm701443n

Reference yield: 79.0%

toluene-4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester → 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one (863888-33-9)

Guidance literature:

With potassium fluoride; [2.2.2]cryptande; In acetonitrile; at 90 ℃; for 0.166667h;

Reference yield:

2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone (863888-30-6) → 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one (863888-33-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: triethylamine; dmap / dichloromethane / 20 °C

3: potassium fluoride; [2.2.2]cryptande / acetonitrile / 0.17 h / 90 °C

With dmap; potassium fluoride; tetrabutyl ammonium fluoride; triethylamine; [2.2.2]cryptande; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

2-(tert-butyl)-4-chloro-5-((4-((2-hydroxyethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

Downstream raw materials:

(2-tert-butyl-4-chloro-5-(4-2-(¹⁸F)fluoroethoxymethyl)-benzyloxy)-2H-pyridazin-3-one