4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester
• CAS No.: 863888-28-2
• Molecular Formula: C₁₇H₂₈O₄Si
• Molecular Weight: 324.492

Synonyms:4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

Chemical Property of 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

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Technology Process of 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

There total 4 articles about 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-(2-hydroxyethoxymethyl)benzoic acid methyl ester (58334-93-3) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester (863888-28-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm701443n

Reference yield: 76.0%

Methyl 4-(bromomethyl)benzoate (2417-72-3) + 2-(tert-butyldimethylsilyloxy)ethanol (102229-10-7) → 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester (863888-28-2)

Guidance literature:

With silver(l) oxide; In dichloromethane; at 20 ℃; for 25h; Darkness; Inert atmosphere;

DOI:10.1002/cmdc.202000085

Reference yield:

Methyl 4-(bromomethyl)benzoate (2417-72-3) + 2-(tert-butyldimethylsilyloxy)ethanol (102229-10-7) → 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester (863888-28-2) + C16H25BrO3Si

Guidance literature:

2-(tert-butyldimethylsilyloxy)ethanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Methyl 4-(bromomethyl)benzoate; In tetrahydrofuran; Inert atmosphere;

DOI:10.1002/cmdc.202000085

upstream raw materials:

4-(2-hydroxyethoxymethyl)benzoic acid methyl ester

tert-butyldimethylsilyl chloride

4-(methoxycarbonyl)benzyl alcohol

Methyl 4-(bromomethyl)benzoate

Downstream raw materials:

2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

2-(tert-butyl)-4-chloro-5-((4-((2-hydroxyethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one

toluene 4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]-ethyl ester

(2-tert-butyl-4-chloro-5-(4-2-(¹⁸F)fluoroethoxymethyl)-benzyloxy)-2H-pyridazin-3-one

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