N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Base Information

Chemical Name:N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide
CAS No.:1449478-59-4
Molecular Formula:C₁₈H₂₄N₄O
Molecular Weight:312.415
Hs Code.:

Synonyms:N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

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Chemical Property of N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

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Technology Process of N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

There total 6 articles about N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1449478-45-8
C₁₆H₂₀N₄O

: 75-03-6
ethyl iodide

: 1449478-59-4
N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; Cooling with ice;
DOI:10.1016/j.ejmech.2013.05.022

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1449478-59-4
N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene / Dean-Stark; Inert atmosphere; Reflux

2.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: potassium carbonate / ethanol / 18 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

5.1: potassium carbonate / acetonitrile / 20 °C / Cooling with ice

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.022

Reference yield:

: 217807-98-2
4-morpholin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid ter-tbutyl ester

: 1449478-59-4
N-(2,5-dimethylphenyl)-5-ethyl-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: potassium carbonate / ethanol / 18 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: potassium carbonate / acetonitrile / 20 °C / Cooling with ice

With potassium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.022