1,3-difluoro-2-(4-iodophenoxy)benzene

Base Information

• Chemical Name: 1,3-difluoro-2-(4-iodophenoxy)benzene
• CAS No.: 1414356-26-5
• Molecular Formula: C₁₂H₇F₂IO
• Molecular Weight: 332.088
• Mol file: 1414356-26-5.mol

Synonyms:1,3-difluoro-2-(4-iodophenoxy)benzene

Chemical Property of 1,3-difluoro-2-(4-iodophenoxy)benzene

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1,3-Difluoro-2-(4-iodophenoxy)benzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-difluoro-2-(4-iodophenoxy)benzene

There total 4 articles about 1,3-difluoro-2-(4-iodophenoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(2,6-difluorophenoxy)aniline (307308-81-2) → 1,3-difluoro-2-(4-iodophenoxy)benzene (1414356-26-5)

Guidance literature:

4-(2,6-difluorophenoxy)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.583333h;

With sodium iodide; In water; at 25 ℃; for 2h;

Reference yield:

2,6-difluorophenol (28177-48-2) → 1,3-difluoro-2-(4-iodophenoxy)benzene (1414356-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.33 h / 0 - 20 °C

1.2: 12 h / 25 - 100 °C

2.1: hydrazine hydrate / methanol / 12 h / 25 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.58 h / 0 °C

3.2: 2 h / 25 °C

With hydrogenchloride; sodium hydride; hydrazine hydrate; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

1-(2,6-difluorophenoxy)-4-nitrobenzene (113965-61-0) → 1,3-difluoro-2-(4-iodophenoxy)benzene (1414356-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / methanol / 12 h / 25 °C / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 0.58 h / 0 °C

2.2: 2 h / 25 °C

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In methanol; water;

upstream raw materials:

4-Fluoronitrobenzene

2,6-difluorophenol

4-(2,6-difluorophenoxy)aniline

1-(2,6-difluorophenoxy)-4-nitrobenzene

Downstream raw materials:

2-[4-(2,6-difluorophenoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

tert-butyl (2R)-2-([4-amino-3-[4-(2,6-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidine-1-carboxylate

3-[4-(2,6-difluorophenoxy)phenyl]-1-[(2R)-pyrrolidin-2-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tert-butyl (3R)-3-[4-amino-3-[4-(2,6-difluorophenoxy)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Refernces

• 1、 -. "Tyrosine kinase inhibitors". . . Retrieved 2014/03/26.
• 2、 -. "REVERSIBLE COVALENT PYRROLO- OR PYRAZOLOPYRIMIDINES USEFUL FOR THE TREATMENT CANCER AND AUTOIMMUNE DISEASES". . . Retrieved 2014/01/09.