N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

Base Information

Chemical Name:N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide
CAS No.:1262786-34-4
Molecular Formula:C₂₉H₃₉N₅O₃S
Molecular Weight:537.726
Hs Code.:

Synonyms:N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

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Chemical Property of N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

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Technology Process of N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

There total 6 articles about N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1828-66-6
morpholine-4-sulfonyl chloride

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

: 1262786-34-4
N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 5h;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 1262786-54-8
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

: 1262786-34-4
N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide; hydrogen / ethanol / 18 h / 20 °C / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 80 °C

With ammonium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 41175-39-7
4-hydroxy-2-phenyl-butanenitrile

: 1262786-34-4
N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}-4-morpholinesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: ammonium hydroxide; hydrogen / ethanol / 18 h / 20 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 80 °C

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.030