4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Base Information

Chemical Name:4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile
CAS No.:1262786-54-8
Molecular Formula:C₂₅H₂₈N₄
Molecular Weight:384.524
Hs Code.:

Synonyms:4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

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Chemical Property of 4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

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Technology Process of 4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

There total 4 articles about 4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 478696-46-7
endo-1-(8-azabicyclo[3.2.1]oct-3-yl)-2-methyl-1H-benzimidazole

: 29940-88-3
4-oxo-2-phenyl-butyronitrile

: 1262786-54-8
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 14025-83-3
3-cyano-3-phenylpropanoic acid ethyl ester

: 1262786-54-8
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran / 2 h / Reflux

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

With lithium borohydride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 41175-39-7
4-hydroxy-2-phenyl-butanenitrile

: 1262786-54-8
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; Dess-Martin periodane; In dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030