N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide
• CAS No.: 1414778-91-8
• Molecular Formula: C₁₂H₂₀N₂O₂S₂
• Molecular Weight: 288.435
• Mol file: 1414778-91-8.mol

Synonyms:N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property of N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide

There total 4 articles about N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-chloropropan-1-amine (14753-26-5) + N,N'-<(ethanodithio)ethano>bis- (23516-74-7) → N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide (1414778-91-8)

Guidance literature:

N,N'-<(ethanodithio)ethano>bis-; With triphenylphosphine; In tetrahydrofuran; water; for 120h; Inert atmosphere; Schlenk technique; Reflux;

3-chloropropan-1-amine; With sodium hydroxide; In tetrahydrofuran; water; for 12h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1039/c8dt04740e

Reference yield:

N-(2-mercaptoethyl)-4-methylbenzenesulfonamide (23516-75-8) + 3-chloropropylamine hydrochloride (6276-54-6) → N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide (1414778-91-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 66 ℃; for 10h;

DOI:10.1016/j.tetlet.2012.09.088 DOI:10.1016/j.tetlet.2012.09.088

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-[2-(3-amino-propylthio)-ethyl]-4-methyl-benzenesulfonamide (1414778-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water; dichloromethane / 12 h / 20 °C

2: triphenylphosphine / water; tetrahydrofuran / 72 h / 66 °C

3: sodium hydroxide / water; tetrahydrofuran / 10 h / 66 °C

With triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.tetlet.2012.09.088 DOI:10.1016/j.tetlet.2012.09.088

upstream raw materials:

3-chloropropan-1-amine

N,N'-<(ethanodithio)ethano>bis-

p-toluenesulfonyl chloride

N-(2-mercaptoethyl)-4-methylbenzenesulfonamide

Downstream raw materials:

N-{N’-[2-(3-propylthio)ethyl]-4-methylbenzenesulfonamide}-[(3-chloropropyl)thio]-acetamide

7-(toluene-4-sulfonyl)-3,10-dithia-7,14-diazacyclotetradecan-1-one

7-(toluene-4-sulfonyl)-3,10-dithia-7,14-diazacyclotetradecan-1-one