2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

Base Information

Chemical Name:2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide
CAS No.:648424-11-7
Molecular Formula:C₁₈H₂₀Cl₂N₂O₂
Molecular Weight:367.275
Hs Code.:

Synonyms:2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

Chemical Property:

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Technology Process of 2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

There total 4 articles about 2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 91800-29-2
2-(propylamino)-1-(pyridin-3-yl)ethan-1-ol

: 648424-11-7
2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; pH=8;
DOI:10.1021/jo051455f

Reference yield:

: 17694-68-7
3-(2-bromoacetyl)pyridine hydrobromide

: 648424-11-7
2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium borohydride / ethanol / 2 h / 20 °C

2: ethanol / 5 h / Heating

3: 82 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; N-methylmorpholine / dimethylformamide / 20 °C / pH 8

With 4-methyl-morpholine; sodium tetrahydroborate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo051455f

Reference yield:

: 118838-57-6
(1-R)-2-bromo-1-(3-pyridinyl)-1-ethanol

: 648424-11-7
2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 5 h / Heating

2: 82 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; N-methylmorpholine / dimethylformamide / 20 °C / pH 8

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo051455f