methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate

Base Information

• Chemical Name: methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate
• CAS No.: 1035573-64-8
• Molecular Formula: C₁₅H₂₁NO₆
• Molecular Weight: 311.335
• Mol file: 1035573-64-8.mol

Synonyms:methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate

Chemical Property of methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate

There total 3 articles about methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

propylamine (107-10-8,42939-71-9) + 2-carboxymethoxy-3,4-dimethoxy-benzoic acid methyl ester → methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate (1035573-64-8)

Guidance literature:

With HATU; In N,N-dimethyl-formamide;

Reference yield: 80.0%

N-(propyl)chloroacetamide (13916-39-7) + methyl 2-hydroxy-3,4-dimethoxy-benzoate (6395-23-9) → methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate (1035573-64-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h; Inert atmosphere; Large scale;

Reference yield:

2-hydroxy-3,4-dimethoxybenzoic acid (5653-46-3) → methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate (1035573-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 18 h / 10 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere; Large scale

With sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

propylamine

N-(propyl)chloroacetamide

methyl 2-hydroxy-3,4-dimethoxy-benzoate

2-hydroxy-3,4-dimethoxybenzoic acid

Downstream raw materials:

2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide

2-{6-[2-(6-chloro-pyrazin-2-yl)-acetyl]-2,3-dimethoxy-phenoxy}-N-propyl-acetamide