[des-tyr¹]-leucine enkephalinamide

Base Information

• Chemical Name: [des-tyr¹]-leucine enkephalinamide
• CAS No.: 82948-92-3
• Molecular Formula: C₁₉H₂₉N₅O₄
• Molecular Weight: 391.47

Synonyms:[des-tyr¹]-leucine enkephalinamide

Chemical Property of [des-tyr¹]-leucine enkephalinamide

Chemical Property:

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Technology Process of [des-tyr¹]-leucine enkephalinamide

There total 17 articles about [des-tyr¹]-leucine enkephalinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Gly-Gly-L-Phe-L-Leu-NH2 (84969-56-2) → [des-tyr1]-leucine enkephalinamide (82948-92-3)

Guidance literature:

DOI:10.1039/c39870000533

Reference yield:

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) → [des-tyr1]-leucine enkephalinamide (82948-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 14.9 percent Chromat. / Et3N; α-chymotrypsin immobilised on Celite / acetonitrile; various solvent(s) / 0.08 h / 30 °C / pH 7.8

2: H₂ / 5percent Pd/C / methanol

With α-chymotrypsin immobilised on Celite; hydrogen; triethylamine; 5percent Pd/C; In methanol; acetonitrile;

DOI:10.1039/b108738j

Reference yield:

Z-Gly-Gly-L-Phe-OCH2CF3 (169676-30-6) → [des-tyr1]-leucine enkephalinamide (82948-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.4 percent Chromat. / Et3N; α-chymotrypsin immobilised on Celite / acetonitrile; various solvent(s) / 0.08 h / 30 °C / pH 7.8

2: 100 percent / diethyl ether

3: 14.9 percent Chromat. / Et3N; α-chymotrypsin immobilised on Celite / acetonitrile; various solvent(s) / 0.08 h / 30 °C / pH 7.8

4: H₂ / 5percent Pd/C / methanol

With α-chymotrypsin immobilised on Celite; hydrogen; triethylamine; 5percent Pd/C; In methanol; diethyl ether; acetonitrile;

DOI:10.1039/b108738j

upstream raw materials:

Z-Gly-Gly-L-Phe-L-Leu-NH₂

amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine

Z-Gly-Gly-L-Phe-OMe

(2S)-amino-4-methylpentanamide hydrochloride

Downstream raw materials:

amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-NH₂

2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine

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