amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Base Information

• Chemical Name: amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
• CAS No.: 81638-88-2
• Molecular Formula: C₄₀H₅₂N₆O₈
• Molecular Weight: 744.888
• Mol file: 81638-88-2.mol

Synonyms:amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Chemical Property of amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

There total 18 articles about amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) + [des-tyr1]-leucine enkephalinamide (82948-92-3) → amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine (81638-88-2)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/b108738j

Reference yield: 85.0%

L-Phe-L-Leu-NH2 (38678-59-0) → amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine (81638-88-2)

Guidance literature:

With subtilisin 8350; triethylamine; In water; N,N-dimethyl-formamide; for 0.75h; pH 8.5-9.0;

DOI:10.1021/ja00159a006

Reference yield: 83.0%

L-Phe-L-Leu-NH2 (38678-59-0) + Boc-Tyr(OBzl)-Gly-Gly-OEt (87423-40-3) → amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine (81638-88-2)

Guidance literature:

With subtilisin 8350; triethylamine; In water; N,N-dimethyl-formamide; for 0.416667h; pH 8.5-9.0;

DOI:10.1021/ja00159a006

upstream raw materials:

L-Phe-L-Leu-NH₂

Boc-Tyr(OBzl)-Gly-Gly-OEt

hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine

O-(N-t-butyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime

Downstream raw materials:

amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-NH₂