(2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Base Information

Chemical Name:(2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether
CAS No.:478491-05-3
Molecular Formula:C₄₉H₅₂O₄Si
Molecular Weight:733.035
Hs Code.:

Synonyms:(2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Suppliers and Price of (2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

There total 6 articles about (2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 76-83-5
trityl chloride

: 478491-18-8
(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

: 478491-05-3
(2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Guidance literature:: With 2,6-dimethylpyridine; tetra-(n-butyl)ammonium iodide; In dichloromethane; at 20 ℃; for 5.5h;
DOI:10.1021/ja028019k

Reference yield:

: 478491-15-5
(3S)-4-(tert-butyldiphenylsilanyloxy)-hydroxy-N-methoxy-N-methylbutyramide

: 478491-05-3
(2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / trifluoromethanesulfonic acid / diethyl ether / 0.5 h / 20 °C

2: 80 percent / DIBAL-H / hexane; tetrahydrofuran / 0.75 h / -78 °C

3: 95 percent / KHMDS / tetrahydrofuran; toluene / 1 h / 20 °C

4: 89 percent / DIBAL-H / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

5: 92 percent / 2,6-lutidine; tetra-n-butylammonium iodide / CH₂Cl₂ / 5.5 h / 20 °C

With 2,6-dimethylpyridine; trifluorormethanesulfonic acid; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/ja028019k

Reference yield:

: 478491-03-1
(S)-4-(((tert-butyldiphenylsilyl)oxy)methyl)oxetan-2-one

: 478491-05-3
(2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethylaluminium chloride / CH₂Cl₂; hexane / 1 h / 20 °C

1.2: 94 percent / CH₂Cl₂ / 2 h / 20 °C

2.1: 77 percent / trifluoromethanesulfonic acid / diethyl ether / 0.5 h / 20 °C

3.1: 80 percent / DIBAL-H / hexane; tetrahydrofuran / 0.75 h / -78 °C

4.1: 95 percent / KHMDS / tetrahydrofuran; toluene / 1 h / 20 °C

5.1: 89 percent / DIBAL-H / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

6.1: 92 percent / 2,6-lutidine; tetra-n-butylammonium iodide / CH₂Cl₂ / 5.5 h / 20 °C

With 2,6-dimethylpyridine; trifluorormethanesulfonic acid; dimethylaluminum chloride; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/ja028019k