(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

Base Information

Chemical Name:(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol
CAS No.:478491-18-8
Molecular Formula:C₃₀H₃₈O₄Si
Molecular Weight:490.715
Hs Code.:

Synonyms:(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

Suppliers and Price of (2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

Chemical Property:

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Technology Process of (2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

There total 5 articles about (2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 478491-17-7
(2E)(5S)-6-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy)hex-2-enoic acid ethyl ester

: 478491-18-8
(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h;
DOI:10.1021/ja028019k

Reference yield:

: 478491-15-5
(3S)-4-(tert-butyldiphenylsilanyloxy)-hydroxy-N-methoxy-N-methylbutyramide

: 478491-18-8
(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / trifluoromethanesulfonic acid / diethyl ether / 0.5 h / 20 °C

2: 80 percent / DIBAL-H / hexane; tetrahydrofuran / 0.75 h / -78 °C

3: 95 percent / KHMDS / tetrahydrofuran; toluene / 1 h / 20 °C

4: 89 percent / DIBAL-H / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

With trifluorormethanesulfonic acid; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/ja028019k

Reference yield:

: 478491-03-1
(S)-4-(((tert-butyldiphenylsilyl)oxy)methyl)oxetan-2-one

: 478491-18-8
(2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylaluminium chloride / CH₂Cl₂; hexane / 1 h / 20 °C

1.2: 94 percent / CH₂Cl₂ / 2 h / 20 °C

2.1: 77 percent / trifluoromethanesulfonic acid / diethyl ether / 0.5 h / 20 °C

3.1: 80 percent / DIBAL-H / hexane; tetrahydrofuran / 0.75 h / -78 °C

4.1: 95 percent / KHMDS / tetrahydrofuran; toluene / 1 h / 20 °C

5.1: 89 percent / DIBAL-H / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

With trifluorormethanesulfonic acid; dimethylaluminum chloride; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/ja028019k