478491-15-5Relevant academic research and scientific papers
Divergent reaction pathways in amine additions to β-lactone electrophiles. An application to β-peptide synthesis
Nelson, Scott G.,Spencer, Keith L.,Cheung, Wing S.,Mamie, Steven J.
, p. 7081 - 7091 (2007/10/03)
β-Lactone electrophiles are subject to regioselective addition-elimination (AE) or SN2 ring opening with various nitrogen-based nucleophiles. Primary and secondary amines promote AE ring opening to deliver products that are the functional equiv
A de novo enantioselective total synthesis of (-)-laulimalide
Nelson, Scott G.,Cheung, Wing S.,Kassick, Andrew J.,Hilfiker, Mark A.
, p. 13654 - 13655 (2007/10/03)
An enantioselective total synthesis of the naturally occurring anticancer agent (-)-laulimalide is described. The synthesis is characterized by extensive use of new reaction methodologies based on catalytic asymmetric acyl halide-aldehyde cyclocondensatio
A synthesis of a C1-C7 building block for the enantiomer of hennoxazole A utilizing a regioselective ring opening of a cyclic acetal
Shioiri, Takayuki,McFarlane, Nigel,Hamada, Yasumasa
, p. 73 - 76 (2007/10/03)
AC1-C7 building block (4) for the enantiomer of hennoxazole A(1), an antivirus and analgesic active marine natural product, was efficiently synthesized from (S)-malic acid utilizing the following key steps: (1) the stereoselective co
