phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

Base Information

Chemical Name:phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate
CAS No.:1465764-07-1
Molecular Formula:C₂₀H₁₆ClNO₄
Molecular Weight:369.804
Hs Code.:

Synonyms:phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

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Chemical Property of phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

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Technology Process of phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

There total 1 articles about phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1426339-58-3
C₁₀H₈ClNO₂

: 102690-46-0
phenyl buta-2,3-dienoate

: 1465764-07-1
phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

Guidance literature:: With (S)-bis[3,5-bis(trifluoromethyl)phenyl](3,3-dimethyl-1,5,7-triazabicyclo-[4.3.0]-non-5-ene-8-yl)methanol; In toluene; at -20 ℃; for 1h; Reagent/catalyst; enantioselective reaction; Inert atmosphere;
DOI:10.1246/cl.130295

Reference yield:

: 1465764-07-1
phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

: 1465764-36-6
C₁₄H₁₂ClNO₄

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 - 5 ℃; for 1h; Inert atmosphere;
DOI:10.1246/cl.130295

Reference yield:

: 1465764-07-1
phenyl 3-[(R)-5H-2-(2-chlorophenyl)-5-methyl-4-oxooxazol-5-yl]-3-butenoate

: 240118-48-3
(2R,3S)-2,3-dimethyl-5-oxo-tetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

2.1: lithium methanolate / methanol / 2.5 h / 0 - 5 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 - 100 °C / Inert atmosphere

4.2: 1 h / 100 °C / Inert atmosphere

With palladium 10% on activated carbon; lithium methanolate; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1246/cl.130295