cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

Base Information

Chemical Name:cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol
CAS No.:1315499-38-7
Molecular Formula:C₂₁H₂₂N₄O₃S
Molecular Weight:410.497
Hs Code.:

Synonyms:cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

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Chemical Property of cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

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Technology Process of cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

There total 4 articles about cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 598-42-5
glycolamide

: 1315495-00-1
N⁴-cyclohexyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

: 1315499-38-7
cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

Guidance literature:: glycolamide; With triethyloxonium tetrafluoroborate; In tetrahydrofuran; at 25 ℃; for 2h; Inert atmosphere;

N⁴-cyclohexyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4,5-diamine; In ethanol; for 3.33333h; Inert atmosphere; Heating;
DOI:10.1021/jm4004895

Reference yield:

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1315499-38-7
cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / Isopropyl acetate / 80 °C / Inert atmosphere

2.1: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethanol / 50 °C

3.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere

3.2: 3.33 h / Inert atmosphere; Heating

With palladium on activated charcoal; hydrogen; triethyloxonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; Isopropyl acetate;
DOI:10.1021/jm4004895

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1315499-38-7
cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / Isopropyl acetate / 80 °C / Inert atmosphere

2.1: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethanol / 50 °C

3.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere

3.2: 3.33 h / Inert atmosphere; Heating

With palladium on activated charcoal; hydrogen; triethyloxonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; Isopropyl acetate;
DOI:10.1021/jm4004895