4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

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Chemical Name:4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid
CAS No.:633302-80-4
Molecular Formula:C₄₄H₄₃ClN₈O₈
Molecular Weight:847.327
Hs Code.:

4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

Synonyms:4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

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Chemical Property of 4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

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Technology Process of 4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

There total 10 articles about 4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 633302-77-9
4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 633302-80-4
4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1039/b303650m

Reference yield:

: 13138-78-8
1-methyl-4-nitro-pyrrol-2-carboxylic acid

: 633302-80-4
4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / H₂SO₄ / diethyl ether / 36 h / 20 °C

2: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

3: 1.3 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

4: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

5: 1.0 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

6: H₂ / Pd/C / methanol / 2 h / 20 °C / 2585.81 Torr

7: 1.35 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

8: 58 percent / TiCl₄ / CH₂Cl₂ / 24 h / 20 °C

With sulfuric acid; hydrogen; titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b303650m

Reference yield:

: 120122-47-6
1-methyl-4-nitro-2-trichloroacetylpyrrole

: 633302-80-4
4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / 80 °C

2: NaOH / tetrahydrofuran; methanol / 20 °C

3: 82 percent / H₂SO₄ / diethyl ether / 36 h / 20 °C

4: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

5: 1.3 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

6: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

7: 1.0 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

8: H₂ / Pd/C / methanol / 2 h / 20 °C / 2585.81 Torr

9: 1.35 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

10: 58 percent / TiCl₄ / CH₂Cl₂ / 24 h / 20 °C

With sodium hydroxide; sulfuric acid; hydrogen; titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b303650m