tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate
CAS No.:944469-63-0
Molecular Formula:C₂₂H₂₉NO₅
Molecular Weight:387.476
Hs Code.:

Synonyms:tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

There total 4 articles about tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₄₃NO₅Si

: 944469-63-0
tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm0701019

Reference yield:

: 944469-62-9
1-bromo-3-(4-methoxybenzyloxy)benzene

: 944469-63-0
tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: CuBr*SMe₂ / tetrahydrofuran / 2 h / -30 °C

2.1: 11.97 g / TBAF / tetrahydrofuran / 0 - 20 °C

With tetrabutyl ammonium fluoride; iodine; magnesium; In tetrahydrofuran;
DOI:10.1021/jm0701019

Reference yield:

: 591-20-8
3-Bromophenol

: 944469-63-0
tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / Cs₂CO₃ / dimethylformamide / 18 h / 20 °C

2.1: Mg; I₂ / tetrahydrofuran / Heating

2.2: CuBr*SMe₂ / tetrahydrofuran / 2 h / -30 °C

3.1: 11.97 g / TBAF / tetrahydrofuran / 0 - 20 °C

With tetrabutyl ammonium fluoride; iodine; caesium carbonate; magnesium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0701019