tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate
CAS No.:944469-64-1
Molecular Formula:C₄₀H₄₆N₄O₇
Molecular Weight:694.828
Hs Code.:

Synonyms:tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

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Technology Process of tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

There total 5 articles about tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944469-62-9
1-bromo-3-(4-methoxybenzyloxy)benzene

: 944469-64-1
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: CuBr*SMe₂ / tetrahydrofuran / 2 h / -30 °C

2.1: 11.97 g / TBAF / tetrahydrofuran / 0 - 20 °C

3.1: triphenylphosphine; di-t-butyl diazocarboxylate / tetrahydrofuran / 20 h / 20 °C

4.1: 11.5 g / Et₃N / Pd₂(dba)3; tri-o-tolylphosphine / dimethylformamide / 16 h / 70 °C

With tetrabutyl ammonium fluoride; iodine; magnesium; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction / 4.1: Stille coupling;
DOI:10.1021/jm0701019

Reference yield:

: C₂₈H₄₃NO₅Si

: 944469-64-1
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 11.97 g / TBAF / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; di-t-butyl diazocarboxylate / tetrahydrofuran / 20 h / 20 °C

3: 11.5 g / Et₃N / Pd₂(dba)3; tri-o-tolylphosphine / dimethylformamide / 16 h / 70 °C

With tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Mitsunobu reaction / 3: Stille coupling;
DOI:10.1021/jm0701019

Reference yield:

: 944469-63-0
tert-butyl (S)-1-hydroxy-3-(3-(4-methoxybenzyloxy)phenyl)propan-2-ylcarbamate

: 944469-64-1
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-t-butyl diazocarboxylate / tetrahydrofuran / 20 h / 20 °C

2: 11.5 g / Et₃N / Pd₂(dba)3; tri-o-tolylphosphine / dimethylformamide / 16 h / 70 °C

With triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Mitsunobu reaction / 2: Stille coupling;
DOI:10.1021/jm0701019