tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

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Chemical Name:tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate
CAS No.:944469-65-2
Molecular Formula:C₃₂H₃₈N₄O₆
Molecular Weight:574.677
Hs Code.:

Synonyms:tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

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Technology Process of tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

There total 6 articles about tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 944469-64-1
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-(4-methoxybenzyloxy)phenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

: 944469-65-2
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 6h; under 3102.97 Torr;
DOI:10.1021/jm0701019

Reference yield:

: 944469-62-9
1-bromo-3-(4-methoxybenzyloxy)benzene

: 944469-65-2
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: CuBr*SMe₂ / tetrahydrofuran / 2 h / -30 °C

2.1: 11.97 g / TBAF / tetrahydrofuran / 0 - 20 °C

3.1: triphenylphosphine; di-t-butyl diazocarboxylate / tetrahydrofuran / 20 h / 20 °C

4.1: 11.5 g / Et₃N / Pd₂(dba)3; tri-o-tolylphosphine / dimethylformamide / 16 h / 70 °C

5.1: 83 percent / H₂ / Pd/C / methanol / 6 h / 50 °C / 3102.97 Torr

With tetrabutyl ammonium fluoride; hydrogen; iodine; magnesium; triethylamine; triphenylphosphine; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction / 4.1: Stille coupling;
DOI:10.1021/jm0701019

Reference yield:

: C₂₈H₄₃NO₅Si

: 944469-65-2
tert-butyl (S)-6-(5-(2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propoxy)pyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 11.97 g / TBAF / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; di-t-butyl diazocarboxylate / tetrahydrofuran / 20 h / 20 °C

3: 11.5 g / Et₃N / Pd₂(dba)3; tri-o-tolylphosphine / dimethylformamide / 16 h / 70 °C

4: 83 percent / H₂ / Pd/C / methanol / 6 h / 50 °C / 3102.97 Torr

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction / 3: Stille coupling;
DOI:10.1021/jm0701019