2-fluorophenyl isopropylcarbamate

Base Information

• Chemical Name: 2-fluorophenyl isopropylcarbamate
• CAS No.: 199585-08-5
• Molecular Formula: C₁₀H₁₂FNO₂
• Molecular Weight: 197.209
• Mol file: 199585-08-5.mol

Synonyms:2-fluorophenyl isopropylcarbamate

Chemical Property of 2-fluorophenyl isopropylcarbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluorophenyl isopropylcarbamate

There total 1 articles about 2-fluorophenyl isopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-fluorophenol (367-12-4) + Isopropyl isocyanate (1795-48-8) → 2-fluorophenyl isopropylcarbamate (199585-08-5)

Guidance literature:

DOI:10.1055/s-2006-926462

Reference yield: 40.0%

2-fluorophenyl isopropylcarbamate (199585-08-5) + trans-geranyl bromide (6138-90-5) → (E)-2-(3,7-dimethylocta-2,6-dien-1-yl)-6-fluorophenyl isopropylcarbamate

Guidance literature:

2-fluorophenyl isopropylcarbamate; With N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; at 25 ℃; for 0.5h;

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 1h;

trans-geranyl bromide; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

DOI:10.1055/s-0039-1690111

Reference yield: 17.0%

2-fluorophenyl isopropylcarbamate (199585-08-5) + trans-geranyl bromide (6138-90-5) → (E)-4-chloro-2-(3,7-dimethylocta-2,6-dien-1-yl)-6-fluorophenyl isopropylcarbamate

Guidance literature:

2-fluorophenyl isopropylcarbamate; With N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; at 25 ℃; for 0.5h;

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 1h;

trans-geranyl bromide; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

DOI:10.1055/s-0039-1690111

upstream raw materials:

2-fluorophenol

Isopropyl isocyanate

Downstream raw materials:

2-chloro-6-fluorophenyl isopropylcarbamate

2-bromo-6-fluorophenyl isopropylcarbamate

2-fluoro-6-iodophenyl isopropylcarbamate

2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate