2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate

Base Information

• Chemical Name: 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate
• CAS No.: 899427-18-0
• Molecular Formula: C₁₃H₂₀FNO₂Si
• Molecular Weight: 269.391
• Mol file: 899427-18-0.mol

Synonyms:2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate

Chemical Property of 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate

There total 5 articles about 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

C13H20FNO2Si + chloro-trimethyl-silane (75-77-4) → 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate (899427-18-0) + isopropyl-carbamic acid 2-fluoro-3,6-bis-trimethylsilanyl-phenyl ester

Guidance literature:

C₁₃H₂₀FNO₂Si; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; pentane; at -78 ℃; for 1h;

chloro-trimethyl-silane; In diethyl ether; pentane; at -78 ℃; for 1h;

With hydrogenchloride; In methanol; at -78 - 20 ℃;

DOI:10.1055/s-2006-926462

Reference yield:

C16H28FNO2Si2 → 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate (899427-18-0)

Guidance literature:

With hydrogenchloride; In methanol; at -78 - 20 ℃;

DOI:10.1055/s-2006-926462

Reference yield:

2-fluorophenyl isopropylcarbamate (199585-08-5) → 2-fluoro-6-(trimethylsilyl)phenyl isopropylcarbamate (899427-18-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TMEDA / diethyl ether; pentane / 0.5 h / 20 °C

2.1: n-butyllithium; TMEDA / diethyl ether; pentane / 1 h / -78 °C

2.2: diethyl ether; pentane / 1 h / -78 °C

3.1: 0.131 g / aq. HCl / methanol / -78 - 20 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In methanol; diethyl ether; pentane;

DOI:10.1055/s-2006-926462

upstream raw materials:

chloro-trimethyl-silane

2-fluorophenyl isopropylcarbamate

2-fluorophenol