(4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride

Base Information

• Chemical Name: (4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride
• CAS No.: 852237-30-0
• Molecular Formula: C₁₆H₂₂N₂O₃*ClH
• Molecular Weight: 326.823
• Mol file: 852237-30-0.mol

Synonyms:(4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride

Chemical Property of (4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride

There total 1 articles about (4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

morpholine (110-91-8,99108-56-2) + 4-benzylmorpholine-2-carboxylic acid hydrochloride (135072-15-0) → (4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride (852237-30-0)

Guidance literature:

4-benzylmorpholine-2-carboxylic acid hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In 1,1-dichloroethane; at 60 - 65 ℃; for 2h;

morpholine; In 1,1-dichloroethane; at 0 - 20 ℃; for 1.75h;

With hydrogenchloride; In water; isopropyl alcohol; for 0.166667h;

Reference yield:

(4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride (852237-30-0) → (4-benzylmorpholin-2-yl)(morpholino)methanone (852237-40-2)

Guidance literature:

With sodium carbonate; In water; toluene; at 20 ℃; for 0.75h;

Reference yield:

(4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride (852237-30-0) + (tetrahydro-2H-pyran-4-yl)magnesium chloride (263257-15-4) → [4-(phenylmethyl)morpholin-2-yl](tetrahydro-2H-pyran-4-yl)methanone (852237-39-9)

Guidance literature:

(4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride; With sodium carbonate; In water; ethyl acetate; for 1h;

(tetrahydro-2H-pyran-4-yl)magnesium chloride; In tetrahydrofuran; toluene; at 22 ℃;

With acetic acid; In tetrahydrofuran; water; toluene; at 22 ℃;

DOI:10.1021/op800247w

upstream raw materials:

morpholine

4-benzylmorpholine-2-carboxylic acid hydrochloride

Downstream raw materials:

(4-benzylmorpholin-2-yl)(morpholino)methanone

[4-(phenylmethyl)morpholin-2-yl](tetrahydro-2H-pyran-4-yl)methanone