Tetrahydropyran-4-ylmagnesium chloride, 0.50 M in THF

Base Information

• Chemical Name: Tetrahydropyran-4-ylmagnesium chloride, 0.50 M in THF
• CAS No.: 263257-15-4
• Molecular Formula: C5H9ClMgO
• Molecular Weight: 144.884
• Mol file: 263257-15-4.mol

Synonyms:tetrahydropyran-4-ylmagnesium chloride;4-tetrahydropyranyl magnesium chloride;chloro(tetrahydro-2H-pyran-4-yl) magnesium;4-tetrahydropyranylmagnesium chloride;4-tetrahydropyranmagnesium chloride;chloro(tetrahydro-2H-pyran-4-yl)magnesium;

Chemical Property of Tetrahydropyran-4-ylmagnesium chloride, 0.50 M in THF

Chemical Property:

• PSA: 9.23000
• LogP: 1.82410

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydropyran-4-ylmagnesiumchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tetrahydropyran-4-ylmagnesium chloride, 0.50 M in THF

There total 4 articles about Tetrahydropyran-4-ylmagnesium chloride, 0.50 M in THF which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorotetrahydro-2H-pyran (1768-64-5) → (tetrahydro-2H-pyran-4-yl)magnesium chloride (263257-15-4)

Guidance literature:

With iodine; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; toluene; at 60 ℃; for 3.5h;

DOI:10.1021/op800247w

Reference yield:

4-chlorotetrahydro-2H-pyran (1768-64-5) + ethylene dibromide (106-93-4) → (tetrahydro-2H-pyran-4-yl)magnesium chloride (263257-15-4)

Guidance literature:

With magnesium; iodine; In tetrahydrofuran; at 60 ℃; Inert atmosphere;

Reference yield:

4-chlorotetrahydro-2H-pyran (1768-64-5) + isopropylmagnesium chloride (1068-55-9) + magnesium (7439-95-4) → (tetrahydro-2H-pyran-4-yl)magnesium chloride (263257-15-4)

Guidance literature:

With methyl iodide; In tetrahydrofuran; at 30 ℃;

upstream raw materials:

4-chlorotetrahydro-2H-pyran

magnesium

isopropylmagnesium chloride

ethylene dibromide

Downstream raw materials:

phenyl(tetrahydro-2H-pyran-4-yl)methanone

C₂₀H₃₁NO₃

(2-{[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-methyl}-4-trifluoromethyl-phenyl)-(tetrahydro-pyran-4-yl)-methanol

[4-(phenylmethyl)morpholin-2-yl](tetrahydro-2H-pyran-4-yl)methanone