(1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

Base Information

Chemical Name:(1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol
CAS No.:124263-03-2
Molecular Formula:C₁₇H₃₄O₂Si
Molecular Weight:298.541
Hs Code.:

Synonyms:(1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

Suppliers and Price of (1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

Chemical Property:

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Technology Process of (1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

There total 9 articles about (1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124263-01-0
ethyl (1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneacetate

: 124263-03-2
(1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 4h;

Reference yield:

: 124177-06-6
(S)-4-(tert-butyldimethylsilyloxy)-3,3-dimethyl-1-cyclohexenecarbaldehyde

: 124263-03-2
(1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaBH₄ / aq. ethanol; tetrahydrofuran / 1 h / 0 - 5 °C

2: 85 percent / propionic acid / 2 h / 130 - 140 °C

3: 67 percent / 46percent hydrofluoric acid / acetonitrile / 4 h / Ambient temperature

4: 79 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

5: 90 percent / lithium tetrahydridoaluminate / diethyl ether / 4 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen fluoride; propionic acid; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 106540-31-2
(+)-(S)-3-(tert-butyldimethylsiloxy)-2,2-dimethylcyclohexanone

: 124263-03-2
(1S,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneethanol

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) sodium hydride / 1.) THF, benzene, 10 min 2.) ca. 12 h, room temperature

2: p-toluenesulfonic acid / benzene / 2 h / Heating

3: NaBH₄ / aq. ethanol; tetrahydrofuran / 1.5 h / 0 - 4 °C

4: cadmium carbonate, mercuric chloride / aq. ethanol / 0.05 h / Heating

5: 100 percent / NaBH₄ / aq. ethanol; tetrahydrofuran / 1 h / 0 - 5 °C

6: 85 percent / propionic acid / 2 h / 130 - 140 °C

7: 67 percent / 46percent hydrofluoric acid / acetonitrile / 4 h / Ambient temperature

8: 79 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

9: 90 percent / lithium tetrahydridoaluminate / diethyl ether / 4 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; cadmium(II) carbonate; hydrogen fluoride; sodium hydride; toluene-4-sulfonic acid; propionic acid; mercury dichloride; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;